The mission of the NIEHS P30 Core Center, Community Health Addressing Regional Maryland Environmental Determinants of Disease (CHARMED) is to build capacity in community-engaged research aimed at understanding the mechanistic links between environmental exposures and adverse health outcomes and translate these findings into action to improve the health and well-being of vulnerable individuals in communities across the greater Maryland region. We are building partnerships with communities of the greater Baltimore region (from Washington, DC through Baltimore, MD and including some regions of Pennsylvania) to address their environmental concerns.